Preliminary Programme

Thursday, 19 September

12:00-14:30

Registration and posters set-up

14:30-15:00

Welcome and Opening of the Congress

Awarding of the Luca Daveggio prize

15:00-16:00

SIBBM Keynote Lecture

Christer Betsholtz (Uppsala, Sweden)
A single-cell perspective on vascular biology

16:00-17:00

Session 1: Protein synthesis and degradation in cancer

Simona Polo (Milan, Italy)
Insights into HECT UB ligases: catalysis, regulation and inhibitors

Michele Carbone (Honolulu, HI, USA)
BAP1 cancer syndrome: how this gene regulate gene x environment interactions

17:00-17:30

Coffee break

17:30-19:00

Flash poster presentations

19:00-22:30

Poster session 1

21:00-22:30

Buffet dinner

Friday, 20 September

9:00-10:00

Fondazione Umberto Veronesi Keynote Lecture

Sandra Schmid (Dallas, TX, USA)
Crosstalk between signaling and endocytosis in cancer cells

10:00-11:00

Session 2: Membrane contacts

Marco Sandri (Padua, Italy)
Mitochondrial dynamics in cellular homeostasis

Antonella De Matteis (Naples, Italy)
ER-Golgi contact site

11:00-11:30

Coffee break

11:30-12:30

Session 3: Cancer microenvironment

Alberto Mantovani (Milan)
Innate immunity, inflammation and cancer: double edged swords

Adriana Albini (Milan)
Inflammation, angiogenesis and the tumor microenvironment as targets for cancer prevention

12:30-13:30

AIRC Keynote Lecture AIRC

Michael W. Young (New York, NY, USA) • 2017 Nobel Laureate in Physiology or Medicine
Role of Drosophila’s blood brain barrier in sleep homeostasis

13:30-15:00

Lunch break

15:00-16:00

Session 4: Circadian clock

Michael Hastings (Cambridge, UK)
Cellular and molecular basis to circadian rhythms in mammals

Paolo Sassone-Corsi (Irvine, CA, USA)
Common threads: metabolism, epigenetics and the circadian clock

16:00-17:00

Keynote Lecture

Pier Paolo Di Fiore (Milan)
Subverted endocytosis and cancer: much more than meets the eyes

17:00-17:30

Coffee break

17:30-19:00

Session 5: Cancer cellular evolution

Alberto Bardelli (Turin)
Adaptive mutability of cancers in response to targeted therapies

Giovanni Ciriello (Lausanne, Switzerland)
Cancer evolutionary templates: from statistical to functional relevance

Francesca Demichelis (Trento)
Cancer evolution studies, one allele at the time

19:00-22:30

Poster session 2

21:00-22:30

Buffet dinner

Saturday, 21 September

9:00-10:00

Keynote Lecture

Maria Rescigno (Milan, Italy)
Microbiota and cancer progression

10:00-11:30

Session 6: Inflammation and immune response

Alessandro Sette (La Jolla, CA, USA)
α-Synuclein-specific T cell reactivity is associated with preclinical and early stages of Parkinson’s disease

Antonella Viola (Padua)
The role of mitochondria in macrophage activation and functions

Haining Yang (Honolulu, HI, USA)
Mechanisms of asbestos carcinogenesis and cancer susceptibility

11:30-12:00

Coffee break

12:00-13:00

The EMBO Keynote Lecture EMBO

Bruce Beutler (Dallas, TX, USA) • 2011 Nobel Laureate in Physiology or Medicine
Using forward genetics to explore immunity in mice

13:00-14:00

Lunch break

14:00-16:00

Parallel Sessions (selected contributions from submitted abstracts)

A. From stress response to tissue development and regeneration

B. Signalling, membrane trafficking and organelle biogenesis

  • From stress response to tissue development and regeneration

    Chairs: Massimo Gulisano, Cristina Mazzoni

    14:00-14:15

    Stefania Farina (Pavia, Italy)
    ALS-linked mutation in FUS protein negatively impact on proper DNA Damage response activation leading to damage accumulation

    14:15-14:30

    Nunzio Vicario (Catania, Italy)
    Neuroglial axis and immune cells role in a mouse model of motoneuronal ablation

    14:30-14:40

    Caterina Gasperini (Genoa, Italy)
    Identification of piRNAs and functional investigation of piRNA-pathway in adult mammalian Neural Progenitor Cells

    14:40-14:55

    Francescopaolo Iavarone (Naples, Italy)
    Cripto modulates macrophage phenotypes and controls endothelial plasticity by restricting EndMT in skeletal muscle injury and Duchene muscular dystrophy

    14:55-15:05

    Alessandra Barbiera (Rome, Italy)
    Role of taurine to counteract the loss of muscle mass and function characteristic of senescent muscle

    15:05-15:20

    Teresa Rinaldi (Rome, Italy)
    Mitochondrial oxidative stress modulates the NEDD8/Rub1 conjugation pathway in S. cerevisiae

    15:20-15:30

    Giuseppe Caruso (Troina, EN, Italy)
    Non-toxic engineered carbon nanodiamond concentations induce oxidative/ntrosative stress, imbalance of energy metabolism and mitochondrial dysfunction in microglial and alveolar basal epithelial cells

    15:30-15:40

    Luisa de Latouliere (Rome, Italy)
    Mice and fishes illuminate diseases: a new era of preclinical oncology models

    15:40-15:50

    Lina Ghibelli (Rome, Italy)
    Anakoinosis: an innovative anticancer therapy targeting the aberrant cancer tissue homeostasis

    15:50-16:00

    Raffaele Strippoli (Rome, Italy)
    Mechanical stretch triggers TGF-β1 autocrine production causal to YAP/Caveolin1 activities: implications in peritoneal fibrotic pathologies

  • Signalling, membrane trafficking and organelle biogenesis

    Chairs: Barbara Belletti, Carmen Valente

    14:00-14:15

    Sirio Dupont (Padua, Italy)
    Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

    14:15-14:30

    Maurizio Renna (Naples, Italy)
    Unconventional secretion of the small heat-shock protein α-Crystallin B requires the autophagic pathway and is controlled by phosphorylation of its serine 59 residue

    14:30-14:40

    Laura Cinque (Pozzuoli, NA, Italy)
    Transcriptional regulation of ER-phagy by MiT/TFE factors controls chondrocyte differentiation and bone formation

    14:40-14:50

    Rosaria Di Martino (Naples, Italy)
    Control systems regulating export from the TGN: a role of an orphan GPCR in basolateral cargo delivery and cell polarity

    14:50-15:00

    Thomas Vaccari (Milan, Italy)
    The SNARE protein SNAP29 at the endoplasmic reticulum arrival sites: unconventional action and a blueprint for kinetochore formation

    15:00-15:15

    Giusi Caldieri (Milan, Italy)
    Connecting the EGFR to the ER: the role of PLCG2 in non-clathrin endocytosis

    15:15-15:30

    Chiara Di Malta (Pozzuoli, NA, Italy)
    Deregulation of MiT/TFE-mTORC1 crosstalk promotes cancer growth

    15:30-15:40

    Simone Patergnani (Ferrara, Italy)
    Antidepressants targeting the ubiquitin-proteasome-autophagy pathway increase mesothelioma response to chemotherapy

    15:40-15:50

    Maria Chiara De Santis (Turin, Italy)
    PI3K-C2γ loss promotes pancreatic cancer through mTOR regulation and metabolic rewiring

    15:50-16:00

    Maria Chiara Masone (Pozzuoli, NA, Italy)
    The PI4P sensor FAPP1 regulates cell invasion by controlling secretion of pro-metastatic factors

16:00-17:00

Coffee break

17:00-18:00

Session 7: Stem cells in development and cancer: from single cell to organoids

Giulio Cossu (Manchester, UK)
Cell mediated exon skipping for the therapy of Duchenne Muscular Dystrophy

Nicola Valeri (London, UK)
Patient-derived organoids for personalized cancer treatment

18:00-18:15

Awarding of the "Guido Berlucchi Foundation" prizes

18:15-19:45

ABCD Assembly

20:30

Social dinner (Salotto Boschi, Bologna)