Programme

Thursday, 19 September

12:00-14:30

Registration and posters set-up

14:30-15:00

Welcome and Opening of the Congress

Awarding of the "Luca Daveggio" prize

15:00-16:00

SIBBM Keynote Lecture

Chair: Pier Paolo Di Fiore (Milan)

Christer Betsholtz (Uppsala, Sweden)
A single-cell perspective on vascular biology

16:00-17:00

Session 1: Protein synthesis and degradation in cancer

Chair: Lucia Di Marcotullio (Rome)

Simona Polo (Milan, Italy)
Insights into HECT UB ligases: catalysis, regulation and inhibitors

Michele Carbone (Honolulu, HI, USA)
BAP1 cancer syndrome: how this gene regulate gene x environment interactions

17:00-17:30

Coffee break

17:30-19:00

Flash poster presentations

Chairs: Carlo Gaetano (Pavia), Giulia Piaggio (Rome)

19:00-22:30

Poster session 1

21:00-22:30

Buffet dinner

Friday, 20 September

9:00-10:00

Fondazione Umberto Veronesi Keynote Lecture

Chair: Paola Defilippi (Turin)

Sandra Schmid (Dallas, TX, USA)
Crosstalk between signaling and endocytosis in cancer cells

10:00-11:00

Session 2: Membrane contacts

Chair: Roberto Sitia (Milan)

Marco Sandri (Padua, Italy)
Mitochondrial dynamics in cellular homeostasis

Antonella De Matteis (Pozzuoli, NA, Italy)
ER-Golgi contact sites

11:00-11:20

Coffee break

11:20-11:30

Gennaro Ciliberto (FISV President)
FISV: mission and activities

11:30-12:30

Session 3: Cancer microenvironment

Chair: Gennaro Ciliberto (Rome)

Alberto Mantovani (Milan, Italy)
Innate immunity, inflammation and cancer: double edged swords

Adriana Albini (Milan, Italy)
Inflammation, angiogenesis and the tumor microenvironment as targets for cancer prevention

12:30-13:30

AIRC Keynote Lecture AIRC

Chair: Rudi Costa (Padua)

Michael W. Young (New York, NY, USA) • 2017 Nobel Laureate in Physiology or Medicine
Role of Drosophila’s blood brain barrier in sleep homeostasis

13:30-15:00

Lunch break

15:00-16:00

Session 4: Circadian clock

Chair: Massimo Santoro (Padua)

Michael Hastings (Cambridge, UK)
Cellular and molecular basis to circadian rhythms in mammals

Paolo Sassone-Corsi (Irvine, CA, USA)
Common threads: metabolism, epigenetics and the circadian clock

16:00-17:00

Keynote Lecture

Chair: Tom Kirchhausen (Boston, MA, USA)

Pier Paolo Di Fiore (Milan, Italy)
Subverted endocytosis and cancer: much more than meets the eyes

17:00-17:30

Coffee break

17:30-19:00

Session 5: Cancer cellular evolution

Chairs: Giuseppe Biamonti (Pavia), Gabriella Minchiotti (Naples)

Alberto Bardelli (Turin, Italy)
Adaptive mutability of cancers in response to targeted therapies

Giovanni Ciriello (Lausanne, Switzerland)
Cancer evolutionary templates: from statistical to functional relevance

Francesca Demichelis (Trento, Italy)
Cancer evolution studies, one allele at the time

19:00-22:30

Poster session 2

21:00-22:30

Buffet dinner

Saturday, 21 September

9:00-10:00

Keynote Lecture

Chair: Carmine Settembre (Pozzuoli, NA)

Maria Rescigno (Milan, Italy)
Microbiota and cancer progression

10:00-11:30

Session 6: Inflammation and immune response

Chairs: Matteo Iannacone (Milan), Antonio Musarò (Rome)

Alessandro Sette (La Jolla, CA, USA)
α-Synuclein-specific T cell reactivity is associated with preclinical and early stages of Parkinson’s disease

Antonella Viola (Padua, Italy)
The role of mitochondria in macrophage activation and functions

Haining Yang (Honolulu, HI, USA)
Mechanisms of asbestos carcinogenesis and cancer susceptibility

11:30-12:00

Coffee break

12:00-13:00

The EMBO Keynote Lecture EMBO

Chair: Carlotta Giorgi (Ferrara)

Bruce Beutler (Dallas, TX, USA) • 2011 Nobel Laureate in Physiology or Medicine
Using forward genetics to explore immunity in mice

13:00-14:00

Lunch break

14:00-16:00

Parallel Sessions (selected contributions from submitted abstracts)

A. From stress response to tissue development and regeneration

B. Signalling, membrane trafficking and organelle biogenesis

  • From stress response to tissue development and regeneration

    Chairs: Massimo Gulisano (Catania), Cristina Mazzoni (Rome)

    14:00-14:15

    Stefania Farina (Pavia, Italy)
    ALS-linked mutation in FUS protein negatively impact on proper DNA damage response activation leading to damage accumulation

    14:15-14:30

    Nunzio Vicario (Catania, Italy)
    Neuroglial axis and immune cells role in a mouse model of motoneuronal ablation

    14:30-14:40

    Caterina Gasperini (Genoa, Italy)
    Identification of piRNAs and functional investigation of piRNA-pathway in adult mammalian Neural Progenitor Cells

    14:40-14:55

    Francescopaolo Iavarone (Naples, Italy)
    Cripto modulates macrophage phenotypes and controls endothelial plasticity by restricting EndMT in skeletal muscle injury and Duchene muscular dystrophy

    14:55-15:05

    Alessandra Barbiera (Rome, Italy)
    Role of taurine to counteract the loss of muscle mass and function characteristic of senescent muscle

    15:05-15:20

    Teresa Rinaldi (Rome, Italy)
    Mitochondrial oxidative stress modulates the NEDD8/Rub1 conjugation pathway in S. cerevisiae

    15:20-15:30

    Giuseppe Caruso (Troina, EN, Italy)
    Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism and mitochondrial dysfunction in microglial and alveolar basal epithelial cells

    15:30-15:40

    Luisa de Latouliere (Rome, Italy)
    Mice and fishes illuminate diseases: a new era of preclinical oncology models

    15:40-15:50

    Lina Ghibelli (Rome, Italy)
    Anakoinosis: an innovative anticancer therapy targeting the aberrant cancer tissue homeostasis

    15:50-16:00

    Raffaele Strippoli (Rome, Italy)
    Mechanical stretch triggers TGF-β1 autocrine production causal to YAP/Caveolin1 activities: implications in peritoneal fibrotic pathologies

  • Signalling, membrane trafficking and organelle biogenesis

    Chairs: Barbara Belletti (Aviano, PN), Carmen Valente (Naples)

    14:00-14:15

    Sirio Dupont (Padua, Italy)
    Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

    14:15-14:30

    Maurizio Renna (Naples, Italy)
    Unconventional secretion of the small heat-shock protein α-Crystallin B requires the autophagic pathway and is controlled by phosphorylation of its serine 59 residue

    14:30-14:40

    Laura Cinque (Pozzuoli, NA, Italy)
    Transcriptional regulation of ER-phagy by MiT/TFE factors controls chondrocyte differentiation and bone formation

    14:40-14:50

    Rosaria Di Martino (Naples, Italy)
    Control systems regulating export from the TGN: a role of an orphan GPCR in basolateral cargo delivery and cell polarity

    14:50-15:00

    Thomas Vaccari (Milan, Italy)
    The SNARE protein SNAP29 at the endoplasmic reticulum arrival sites: unconventional action and a blueprint for kinetochore formation

    15:00-15:15

    Elisa Barbieri (Milan, Italy)
    Connecting the EGFR to the ER: the role of PLCG2 in non-clathrin endocytosis

    15:15-15:30

    Chiara Di Malta (Pozzuoli, NA, Italy)
    Deregulation of MiT/TFE-mTORC1 crosstalk promotes cancer growth

    15:30-15:40

    Simone Patergnani (Ferrara, Italy)
    Antidepressants targeting the ubiquitin-proteasome-autophagy pathway increase mesothelioma response to chemotherapy

    15:40-15:50

    Maria Chiara De Santis (Turin, Italy)
    PI3K-C2γ loss promotes pancreatic cancer through mTOR regulation and metabolic rewiring

    15:50-16:00

    Rossella Venditti (Pozzuoli, NA, Italy)
    The PI4P sensor FAPP1 regulates cell invasion by controlling secretion of pro-metastatic factors

16:00-17:00

Coffee break

17:00-18:00

Session 7: Stem cells in development and cancer: from single cell to organoids

Chair: Cecilia Bucci (Lecce)

Giulio Cossu (Manchester, UK)
Cell mediated exon skipping for the therapy of Duchenne Muscular Dystrophy

Nicola Valeri (London, UK)
Patient-derived organoids for personalized cancer treatment

18:00-18:15

Awarding of the "Guido Berlucchi Foundation" prizes

18:15-19:45

ABCD Assembly

20:30

Social dinner (Salotto Boschi, Bologna)

POSTERS

The poster's maximum size is A0 (841 x 1189 mm; width x height).

Correct format... poster should be PORTRAIT    poster should NOT be LANDSCAPE Wrong format...

All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned. You are kindly invited to put up your poster upon arrival, from Thursday at 14:00 onwards, and in time for the first poster session. Posters should be taken down before 18:00 on Saturday, 21 September.

 

  • Thursday, 19 September • 19:00-22:30

    P.A1 • Tiziana Anelli • Milan
    Decidualization entails profound architectural and functional readjustments of the secretory pathway in endometrial stromal cells

    P.A3 • Eustachio Attico • Modena
    Identification of markers to univocally distinguish human oral mucosa epithelium from cornea and conjunctival tiussues

    P.A5 • Francesco Capradossi • Rome
    Post therapy cancer repopulation: from DNA damage to tissue regeneration

    P.A7 • Gabriele D'Uva • Milan
    Direct stimulation of cardiomyocyte regenerative plasticity by steroid hormone modulation

    P.A9 • Chiara De Leonibus • Naples
    Study of the function and physiological roles of the ER-phagy receptor FAM134B during skeletal development in Medaka model

    P.A11 • Giovanni Dothel • Bologna
    Secondary bile acid effect on neuronal sprouting evoked by mast cells – an in vitro model of neuro-immune interaction

    P.A13 • Marialucia Gallorini • Chieti
    Hyaluronic acid enhances recovery from inflammation through the activation of Nrf2-related pathways in human tenocytes

    P.A15 • Nicoletta Guaragnella • Bari
    Exploring the therapeutic potential of 6-Thioguanine and its Analogs in the treatment of BRCA2-deficient castration-resistant prostate cancers

    P.A17 • Giovanna Lattanzi • Bologna
    Inhibition of inflammatory cytokines improves the disease phenotype in laminopathic cells

    P.A19 • Marina Mapelli • Milan
    Molecular crosstalk between fate determination and orientation in epithelial cell divisions

    P.A21 • Simona Martinotti • Alessandria
    Honey-Mediated Wound Healing: H2O2 Entry through AQP3

    P.A23 • Elisa Mentegari • Pavia
    Characterisation of a novel alternative end-joining pathway independent from DNA-PKcs

    P.A25 • Tatiana Pinheiro Tiago • Modena
    HSPB3 and HSPB2: unexpected functions in the regulation of nuclear homeostasis

    P.A27 • Elia Ranzato • Alessandria
    Elevated GRP78 expression in malignant mesothelioma

    P.A29 • Simone Sabbioni • Milan
    A RBX1/FBXW8-based SCF-type E3 ligase complex mediates Numb degradation in breast cancer

    P.A31 • Valeria Valente • Naples
    Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice

    P.B1 • Filippo Acconcia • Rome
    The natural ERα L370F and E471D mutations found in metastatic breast cancers are resistant to classic and novel anti-estrogens

    P.B3 • Mattia Apollonio • Trieste
    Regulation of tumor suppressor DAB2IP by mechanical cues

    P.B5 • Elisa Barbieri • Milan
    Role of ER contact sites, calcium and mitochondria in EGFR endocytosis

    P.B7 • Leonardo Barzaghi • Milan
    RAB5 family members in the control of phase transition during collective motion and cancer progression

    P.B9 • William Blalock • Bologna
    AKT-depedent phosphorylation of the adenosine deaminases, ADAR1 and ADAR2, on a conserved threonine residue in the catalytic domain differentially inhibits deaminase activity

    P.B11 • Claudia Busonero • Rome
    Ouabain induces ERα degradation and prevent 17β-estradiol (E2)-induced breast cancer cell proliferation

    P.B13 • Concettina Cappadone • Bologna
    Magnesium deficiency regulates proliferation of human osteosarcoma cells: single cell magnesium distribution by XRFM and STXM techniques

    P.B15 • Barbara Colella • Pesche (IS)
    Glioblastoma-Initiating Cells: a tool to study autophagy role in GBM pathogenesis

    P.B19 • Alberto Danese • Ferrara
    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy (LHON)

    P.B21 • Abhishek Derle • Turin
    Role of PI3KC2A in Modulating the Glucose Homeostasis

    P.B23 • Giorgia Di Lorenzo • Pozzuoli (NA)
    Regulation of cellular metabolism by ER-phagy

    P.B25 • Maristella Laggetta • Ancona
    In vitro pro-inflammatory effects of nongluten ATIs obtained from different wheat species

    P.B27 • Miriam Gaggianesi • Palermo
    A synthetic lethal approach: Sam68 and Rad51 inhibition for the eradication of breast cancer stem cells

    P.B29 • China Genchi • Milan
    A comprehensive strategy to characterize new Notch regulators

    P.B31 • Federico Giulitti • Rome
    Different response to oleic acid administration in hepatocellular carcinoma vs non tumorigenic hepatocyte cell lines

    P.B33 • Daniela Guarnieri • Fisciano (SA)
    The study of the intracellular fate of nanomaterials: how to design safe and effective drug delivery systems

    P.B35 • Andrea Lamarca • Milan
    Mechanisms of assembly and function of plasma membrane–associated platforms at the front of migrating cells

    P.B37 • Ludovica Lospinoso Severini • Rome
    SALL4A is a new positive regulator of Hedgehog signalling involved in medulloblastoma tumorigenesis

    P.B39 • Stefano Marchesi • Milan
    IRSp53 controls kidney morphogenesis through regulation of epithelial polarity and lumenogenesis

    P.B41 • Fabiola Mascanzoni • Naples
    Golgi unlinking is essential for correct spindle formation and cytokinesis

    P.B43 • Valentina Morra • Pozzuoli (NA)
    Role of the PI(4,5)P2 5-phosphatase OCRL at the synapse

    P.B45 • Dora Natalini • Turin
    Regulation of mevalonate pathway by p140Cap in breast cancer cells

    P.B47 • Antonio Pezone • Naples
    Targeted G and C DNA oxidation couples histone and DNA methylation cycles to drive transcription induced by nuclear hormones

    P.B49 • Prathyush Pothukuchi • Naples
    Grasp55 regulates glycosphingolipid biosynthesis by controlling the localization of glycosylation enzymes

    P.B51 • Danilo Ranieri • Rome
    Role of PKCε and PKCα in the control of the epithelial-mesenchymal transition induced by the FGFR2 altered splicing

    P.B53 • Simona Ricciardi • Pozzuoli (NA)
    Role of phosphatidylserine (PS) and PS binding proteins in ER-Golgi contact sites

    P.B55 • Riccardo Rizzo • Naples
    From Golgi dynamics to glycan processing to function: GOLPH3 retrotransports selected glycoenzymes across maturing cisternae to generate growth-promoting glycosphingolipid patterns

    P.B57 • Emanuela Senatore • Naples
    Coupling cAMP signalling to primary ciliogenesis by a TBC1D31-centered centrosomal complex

    P.B59 • Michela Sgubin • Trieste
    HMGA1/p27/stathmin axis promotes migration in triple negative breast cancer (TNBC) cells

    P.B61 • Leopoldo Staiano • Pozzuoli (NA)
    A combined in vitro and in vivo approach for the identification of correctors of Lowe Syndrome

    P.B63 • Luana Tomaipitinca • Rome
    c-FLIP protein regulates autophagic flux by interacting with Beclin-1 and influencing its stability

    P.B65 • Rossella Venditti • Pozzuoli (NA)
    Regulation and function of endoplasmic reticulum-Golgi contact sites

    P.B67 • Narender Kumar • Naples
    A cell-autonomous PD-1/PD-L1/2 circuit promotes proliferation and motility of thyroid cancer cells by potentiating the Ras/Erk signalling cascade

    P.C1 • Davide Adamo • Modena
    Human airway epithelial cell expansion: fittest culture conditions for tissue engineering applications

    P.C3 • Adriana Amaro • Genoa
    Secondary somatic driver mutations in G-protein related pathways and mutation signatures in uveal melanoma

    P.C5 • Matteo Astone • Padua
    Clock ticks during angiogenesis: dissecting the endothelial role of circadian clock gene Bmal1

    P.C9 • Chiara Bernardini • Ozzano Emilia (BO)
    Effect of H2S on porcine Vascular Wall-Mesenchymal Stem Cell physiology

    P.C11 • Amani Bouzidi • Rome
    Serine and glycine rewire lung  adenocarcinoma metastases metabolism

    P.C13 • Licia Bressi • Bologna
    P53 sustains oxidative metabolism and delays the energetic collapse caused by targeting respiratory complex I in combination with low glucose

    P.C15 • Electra Brunialti • Milan
    Morpho-functional analysis of microglia in a cell culture model of Gaucher disease

    P.C17 • Gaia Butera • Padua
    Mitochondrial adaptation in parvalbumin knockout muscle fibers

    P.C19 • Andrea Castiglioni • Milan
    NCAM1/CD56 is a determinant of self-renewal and tumorigenic ability in prostate cancer stem cells

    P.C21 • Francesca Chiarini • Bologna
    Lamin A behaves as a tumor suppressor in Ewing Sarcoma triggering neural differentiation and reducing cell migration and invasion

    P.C23 • Claudia Contadini • Rome
    SRC-dependent phosphorylation of Caspase-8 on Tyr380 contributes to NFkB activation and inflammatory tumor microenvironment in Glioblastoma

    P.C25 • Valeria Cutillo • Milan
    Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization

    P.C27 • Michela Damizia • Rome
    RANBP2: a nucleoporin with key roles in SUMOylation of mitotic proteins

    P.C29 • Maria Giovanna de Marino • Busto Arsizio
    ERG promotes the methylation reprogramming in prostate cancer onset

    P.C31 • Donatella Delle Cave • Naples
    TGF-β promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the L1CAM

    P.C33 • Anna Di Bona • Padua
    Generation and phenotyping of novel knock-in (KI) mouse models of Arrhythmogenic Cardiomyopathy (AC)

    P.C35 • Francesco Di Meo • Naples
    In vitro and in vivo anticancer activity of curcumin standardized extract on mesothelioma

    P.C37 • Riccardo Turchi • Rome
    Frataxin deficiency causes brown adipose tissue dysfunctions: possible implication in diabetes development in Friedreich’s ataxia

    P.C39 • Federica Feo • Naples
    Functional characterization of the transcription factor FOXE1 in the Non-Melanoma Skin Cancers tumorigenesis

    P.C41 • Manuela Ferrara • Rome
    HIPK2/spastin axis: cytokinesis failure and tumorigenesis in pancreatic cancer

    P.C43 • Diego Ferreri • Rome
    Unmasking the role of Drosophila Tip60 chromatin remodelling complex in male meiosis and spermatogenesis

    P.C47 • Rosaria Anna Fontanella • Rome
    Functional and molecular characterization of a metastatic prostate cancer PC3 subpopulation expressing CD44v8-10

    P.C49 • Antonio Galeone • Milan
    Regulation of BMP signaling by N-glycanase 1 (NGLY1)

    P.C51 • Ramesh Gandusekar • Busto Arsizio
    Regulation of H2B monoubiquitination (H2BK120) by UHRF1 in Colorectal Cancer

    P.C53 • Eugenia Giuliani • Rome
    Notch3 contributes to T-cell leukemia growth via regulation of the unfolding protein response

    P.C55 • Marika Guerra • Rome
    Splicing dysregulation of genes encoding for synaptic proteins as risk factor in autism spectrum disorder

    P.C57 • Aymone Gurtner • Rome
    Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

    P.C59 • Myriam Hsu • Turin
    Several models of skeletal muscle wasting display altered iron metabolism

    P.C61 • Francesco Lasorsa • Bari
    Investigation of pathogenetic mechanisms of AGC1 deficiency in iPS cells-derived neuron progenitor cells of patient

    P.C63 • Mattia Lauriola • Bologna
    Glucocorticoid receptor modulates EGFR feedback in the acquisition of resistance to monoclonal antibodies

    P.C65 • Debora Libetti • Milan
    Role of NF-YA isoforms in mouse Embryonic Stem Cells

    P.C67 • Rossella Lucà • Monterotondo (RM)
    MDM4 function and its prognostic potential in ovarian cancer progression

    P.C69 • Jessica Marinello • Bologna
    Development of new G4 binders in cancer therapy: synthesis, biophysical and biological studies of hydrazones derivatives

    P.C71 • Martina Mazzeschi • Bologna
    Pharmacological inhibition of the ALK/MET axis elicits therapeutic potential in consensus molecular subtype 1 colon cancer patients

    P.C73 • Giovanni Messina • Rome
    Evolutionary conserved recruitment of ATP-dependent chromatin remodelling complexes to mitotic apparatus prevent failure of mitosis and genome instability

    P.C75 • Sonia Missiroli • Ferrara
    Loss of PML promotes NLRP3 inflammation-associated cancer in a P2X7 dependent manner

    P.C77 • Halenya Monticelli • Padua
    Role of mitochondrial Ca2+ uniporter in breast cancer

    P.C79 • Giampaolo Morciano • Ferrara
    Novel polymorphisms in ATP5G1-3 genes are associated to poor clinical outcomes in patients affected by Myocardial Infarction

    P.C81 • Francesca Nardozza • Rome
    Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance

    P.C83 • Francesco Nicassio • Milan
    MicroRNA degradation in human physiology and pathology

    P.C85 • Simona Paglia • Bologna
    A neurogenic model of adult brain cancer in Drosophila

    P.C87 • Harikrishnareddy Paluvai • Udine
    Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favours cell transformation

    P.C89 • Annalisa Pecoraro • Naples
    Cyclin D1 and E2F1: novel targets of uL3 in cancer cell response to ribosomal stress

    P.C91 • Mariasole Perrone • Ferrara
    Loss of PML reduces radiotherapy efficacy through NLRP3 inflammasome activation

    P.C93 • Alex Pezzotta • Segrate (MI)
    A new candidate gene involved in nervous system myelination: functional in-vivo validation using a zebrafish model system

    P.C95 • Giovanna Picone • Bologna
    Osteogenic differentiation of osteosarcoma cells: role of Mg in the early stages of mineral formation of hydroxyapatite

    P.C97 • Fabrizio Pizzetti • Bologna
    Interplay between CYYR1 gene and Sonic hedgehog pathway: from zebrafish myogenesis to a potential role in rhabdomyosarcoma disease

    P.C99 • Federica Polverino • Rome
    Spindle orientation is regulated by the Aurora-A/TPX2 axis and contributes to faithful chromosome segregation

    P.C101 • Gian Luca Rampioni Vinciguerra • Aviano (PN)
    p27kip1 regulates haematopoiesis by inducing Notch signalling pathway

    P.C103 • Paola Rovella • Rome
    Importin beta-1 regulates the centromeric protein CENP-F during mitosis

    P.C105 • Chiara Salis • Rome
    Long non-coding RNA MALAT-1 acts as a master controller of cellular metabolism in prostate cancer

    P.C107 • Silvia Sberna • Milan
    Characterization of novel YAP/TAZ regulators

    P.C109 • Emanuela Scavo • Palermo
    Cancer stem cells define thyroid cancer heterogeneity

    P.C111 • Silvia Sideri • Rome
    Role of toll like receptors stimulation in the mechanism involved in radioresistance of prostate cancer

    P.C113 • Stefano Sol • Naples
    Epidermal p63 is essential to control systemic levels of TSLP through repression of KLK6

    P.C115 • Silvia Sorrentino • Rome
    Temozolomide effect on glioblastoma stem cell proliferation and apoptosis is enhanced by Levetiracetam treatment

    P.C117 • Camilla Tombari • Trieste
    Dissecting the oncogenic functions of mutant P53 R249S in hepatocellular carcinoma

    P.C119 • Nesrine Trabelsi • Tunis, Tunisia
    Notch pathway: bioinformatic analysis of related transcription factors within bladder cancer types and subtypes

    P.C121 • Chiara Turco • Rome
    Induction of ID4 protein contributes to tumor-associated macrophages reprogramming in breast cancer

    P.C123 • Roberta Vazzana • Milan
    The role of fatty acids on the metabolic reprogramming of breast cancer cells

    P.C125 • Elisabeth Wyart • Turin
    Altered iron metabolism promotes cancer cachexia

    P.C127 • Michele Zocchi • Busto Arsizio
    Identifying cancer driver transcripts in ERG+/PTEN- RWPE-1 PCa onset in vitro model

  • Friday, 20 September • 19:00-22:30

    P.A2 • Andrea Graziani • Turin
    Colon carcinoma (C26) conditioned medium attenuates the adrenergic signaling in C2C12 muscle cell line

    P.A4 • Ilaria Camponeschi • Rome
    Lipid metabolism connects the response to oxidative stress and longevity in yeast

    P.A6 • Vittoria Cenni • Bologna
    Emerin post-translational modifications are affected during early phase of oxidative stress response

    P.A8 • Luisa de Latouliere • Rome
    Mice and fishes illuminate diseases: a new era of preclinical oncology models

    P.A10 • Isabella Manni • Rome
    Imaging of proliferation during mammary tumorigenesis reveals a crosstalk between cancer and host macroenviroment

    P.A12 • Simone Fonte • Rome
    Loss of the Hedgehog pathway suppressor KCASH2 in mouse leads to mild cerebellar phenotype and altered behaviour

    P.A14 • Elena Genovese • Modena
    Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

    P.A16 • Lucia Infantino • Pavia
    Cell metabolism influences the splicing program of SRSF1 transcripts

    P.A18 • Giacomo Donati • Turin
    Integrating genetics screening approaches to identify chromatin key factors of epidermal cell plasticity

    P.A20 • Serena Marcozzi • Rome
    Protection from cisplatin-induced ovarian damage by human mesenchymal stromal cells in vitro

    P.A22 • Silvia Masciarelli • Rome
    Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce AML cell death

    P.A24 • Giorgia Pallafacchina • Padua
    MCU-mediated mitochondrial Ca2+ uptake is required for zebrafish motor neuron network and skeletal muscle development and adult tissue physiology

    P.A26 • Erica Priori • Pavia
    Oxidative stress and inflammatory pathways evaluation in prolidase deficient mice: a cerebellar study during postnatal development

    P.A28 • Giovanna Rigillo • Modena
    The transcription factor NF-Y is required for satellite stem cell proliferation and skeletal muscle tissue repair

    P.A30 • Simona Sala • Milan
    Characterization of HECW1 role in neuronal homeostasis

    P.A32 • Valentina Vapore • Rome
    Yeast response to the expression of human proteins involved in serpinopathies

    P.B2 • Ilenia Agliarulo • Naples
    Identification of new glycosylation-related oncogenes in non-small cell lung cancer

    P.B4 • Lucia Barazzuol • Padua
    In vitro and in vivo investigation of intracellular organelle contacts with novel modular genetically encoded sensors

    P.B6 • Stefania Bartoloni • Rome
    An unexpected role for 17β-estradiol-induced replication stress in breast cancer cell proliferation

    P.B8 • Arianna Bellazzo • Trieste
    Cell-autonomous and cell non-autonomous downregulation of the tumor suppressor DAB2IP by microRNA-149-3p promotes cancer progression by microenvironment remodeling

    P.B10 • Mara Brancaccio • Turin
    Morgana intracellular and extracellular functions in breast cancer progression

    P.B12 • Miriam Caimano • Rome
    Self-assembling polymers for glabrescione b delivery for hedgehog-dependent tumor treatment

    P.B14 • Natascia Caroccia • Ferrara
    Investigation on the molecular mechanisms involved in melatonin action as neuroprotective agent

    P.B16 • Sara Colombo • Milan
    Role of rare missense variants of the human β4 subunit in the expression and surface exposure of α3β4 nicotinic receptors

    P.B18 • Giulia Cricrì • Monza
    Effect of activinA on b-cell precursor acute lymphoblastic leukemia (BCP-ALL) cell vesiculation

    P.B20 • Angela Della Sala • Turin
    cAMP regulation by a PI3Kg mimetic peptide as a therapeutic strategy to restore CFTR function

    P.B22 • Simone Di Franco • Palermo
    Visceral adiposity drives colon cancer progression

    P.B24 • Alessandra Esposito • Pozzuoli (NA)
    A non-canonical mTOR signaling mediated by Rag GTPases modulates TFEB activity

    P.B26 • Francesca Finetti • Siena
    The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases

    P.B28 • Camilla Galli • Milan
    Dynamic hand-in-hand cooperation between spectrin and actin during mammalian cell mechanoresponses

    P.B30 • Luisa Gesualdi • Rome
    ERK role in the c-MET-mediated proliferating behaviour of NT2D1 non-seminoma cells

    P.B32 • Paolo Grumati • Pozzuoli (NA)
    ER-phagy receptors and co-receptors for specific ER turnover

    P.B34 • Flora Guerra • Lecce
    Extracellular vesicle secretion is mediated by RAB7: implications of late endocytic impairment in cisplatin chemoresistance

    P.B36 • Erica Leonetti • Rome
    c-Met-mediated pathway in malignant behaviour acquisition of NT2D1 non-seminoma cells: role of PI3K/AKT and c-Src adaptors

    P.B38 • Valeria Malacarne • Turin
    DGKα controls glioblastoma tumorigenesis by regulating β1 integrin endocytosis and focal adhesion turnover

    P.B40 • Maria Vittoria Marvi • Bologna
    Inositide-dependent signalling in low- and high-grade gliomas

    P.B42 • Maria Caterina Mione • Trento
    Role of Bap1 in the biogenesis and function of extracellular vesicles in  zebrafish melanoma

    P.B44 • Michela Napolitano • Naples
    Mechanisms of CtBP1-S/BARS-mediated mitotic Golgi fragmentation

    P.B46 • Gaia Pedriali • Ferrara
    New permeability transition pore inhibitors for the treatment of reperfusion damage

    P.B48 • Elena Piretto • Milan
    EGFR trafficking and signalling: insights from mathematical modelling

    P.B50 • Emanuela Pupo • Candiolo
    TBC1D7, a subunit of the TSC1/TSC2 complex, elevates glycolysis in breast cancer by promoting mTORC2 signaling

    P.B52 • Paolo Remondelli • Baronissi (SA)
    PERK-mediated Unfolded Protein Response activation and oxidative stress in PARK20 fibroblasts

    P.B54 • Veronica Riccioni • Rome
    Identification of RNA Binding Proteins (RBPs) regulating sequence-specific miRNA sorting in exosomes

    P.B56 • Anna Scotto Rosato • Naples
    TRPML1 links lysosomal calcium to autophagosome biogenesis

    P.B58 • Maria Concetta Sergio • Pozzuoli (NA)
    Vesicular trafficking is required for the arrival and retrieval of Syntaxin 17 from autophagosomes

    P.B60 • Diletta Siciliano • Pozzuoli (NA)
    Analysis of the physiological relevance of TFEB phosphorylation in vivo

    P.B62 • Claudia Tito • Rome
    Long non-coding RNAs contribution to cell migration and lipid metabolism in thymic epithelial tumor cells

    P.B66 • Lucrezia Zerillo • Naples
    Dysregulation of autophagy has a potential role in Synj1-associated early-onset parkinsonism

    P.C2 • Serena Aleo • Bologna
    Mitochondrial alterations in lysosomal storage disorders: is this the case of fabry disease?

    P.C4 • Mohammad Salik Zeya Ansari • Rome
    Identification of novel p300/CBP selective HAT inhibitor in lung cancer as a future therapeutic strategy by epigenetic therapy

    P.C6 • Denisa Baci • Varese
    Acetyl-L-carnitine (ALCAR), novel anti-inflammatory and anti-angiogenic agent in prostate cancer

    P.C7 • Marina Bellet • Perugia
    The circadian clock controls the outcome of fungal infections

    P.C8 • Silvia Belluti • Modena
    Switch of NF-YA splice variants in prostate cancer development and progression

    P.C10 • Bartolo Bono • Pavia
    Kinetic characterization of CK1ε and DDX3X interplay

    P.C12 • Enrico Bracco • Orbassano (TO)
    Finding novel roles for large HERC E3-ubiquitin ligases in Dictyostelium and leukemic cells

    P.C14 • Elisabetta Broseghini • Bologna
    Understanding the biology of multiple primary melanoma

    P.C16 • Samantha Bruno • Bologna
    Deep hypoxia and the genomic background cooperate to shape the metabolic profile of acute myeloid leukemia cells

    P.C18 • Serena Carra • Modena
    Defective ribosomal products (DRiPs) challenge nuclear function by impairing nuclear condensate dynamics

    P.C20 • Mariano Catanesi • L'Aquila
    YAP/TAZ mechano-transduction as the underlying mechanism of neuronal differentiation induced by reduced graphene oxide

    P.C22 • Barbara Ciani • Sheffield, United Kingdom
    ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

    P.C24 • Salvatrice Ciccarese • Bari
    Evolution of the T cell receptor (TR) loci in mammalian adaptive immune response

    P.C26 • Michele d'Angelo • L'Aquila
    The PPARα selective antagonist, GW6471 inhibits cell growth in breast cancer stem cells inducing energy imbalance and metabolic stress

    P.C28 • Luca De Feo • Milan
    Molecular characterisation of transplanted neural progenitor cells in a multiple sclerosis animal model

    P.C30 • Giorgia De Simone • Milan
    Spatiotemporal dynamics and genomic landscape of CD8+T cells undergoing intrahepatic priming unveil IL-2 as a key immunotherapy component against chronic HBV infection

    P.C32 • Francesca Delle Monache • Rome
    Uncovering the role of the Tip60 chromatin remodelling complex in Drosophila cell division

    P.C34 • Lucia Di Marcotullio • Rome
    Oncogenic role of the aminopeptidase ERAP1 in Hedgehog-dependent cancer

    P.C36 • Francesca Fabretti • Rome
    Dual role of NBS1 in SHH-dependent medulloblastoma

    P.C38 • Albina Fejza • Aviano (PN)
    Emilin 2 as a regulator of vascular efficiency

    P.C40 • Manuela Ferracin • Bologna
    Evaluation of cGAS/STING expression as a marker of tumor immunogenicity

    P.C42 • Beatrice Ferrari • Pavia
    A new platinum-based prodrug candidate: its anticancer effects and in vitro approaches to understand novel target to treat Glioblastoma multiforme

    P.C44 • Nicoletta Filigheddu • Novara
    The role of vitamin D binding protein in the onset of cancer cachexia - beyond vitamin D transport 

    P.C46 • Fabrizio Fontana • Milan
    δ-Tocotrienol induces mitochondrial dysfunction and inhibits glycolysis in prostate cancer cells

    P.C48 • Valeria Fumagalli • Milan
    The role of group 1 innate lymphoid cells (ILCs) in liver immunopathology

    P.C50 • Gloria Ganduscio • Palermo
    Preliminary evaluation of CD44v6/PD-L1 expression as new therapeutic target in CR-CSCs

    P.C52 • Sabrina Garbo • Rome
    A lncRNA HOTAIR mutant form counteracts the Epithelial-to-Mesenchymal Transition (EMT) by interfering with Snail function

    P.C54 • Luca Gozzelino • Turin
    Characterization of PI3KC2β in the pathogenesis of Focal Epilepsy

    P.C56 • Eugenia Guida • Rome
    BRAFV600E mutation in combination with loss of tumor suppressor Pten in adult Neural Stem/Progenitor Cells induces glioma formation

    P.C58 • Benjamin Hershey • Milan
    Tumor ecology, an investigation into the functional role of intra-tumoral metabolic heterogeneity

    P.C60 • Luisa Iommarini • Bologna
    Induction of pseudo-normoxia to prevent hypoxic adaption in tumorigenesis

    P.C62 • Ivana Kurelac • Bologna
    Targeting mitochondrial complex I in cancer triggers macrophage-mediated survival mechanisms

    P.C64 • Elisa Lepore • Rome
    Metabolic changes associated with muscle expression of SOD1G93A

    P.C66 • Ilaria Lorenzon • Aviano (PN)
    Inhibition of SGK2, a novel autophagy modulator, sensitizes cancer cells to platinum drugs

    P.C68 • Natascia Malerba • San Giovanni Rotondo(FG)
    Cell modelling and electrophysiological characterization to dissect the pathogenic consequences of G-protein beta 5 subunit mutations

    P.C70 • Luisa Marracino • Ferrara
    17β-Estradiol-mediated modulation of  Notch1  in murine macrophage cell line Raw 264.7

    P.C72 • Diego Medina • Naples
    Repositioning of FDA-approved drugs for the treatment of Mucopolysaccharidoses (MPSs)

    P.C74 • Stefano Miglietta • Bologna
    Role of MCJ/DNAJC15 in mitochondrial metabolism rewiring of chemoresistant ovarian cancer cells

    P.C76 • Francesca Montani • Milan
    Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: a retrospective consecutive study

    P.C78 • Pascale Monzo • Milan
    Implication of formins in the regulation of mechanoproperties of invasive gliomas

    P.C80 • Francesco Morra • Naples
    Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma

    P.C82 • Francesco Naso • Rome
    Aurora-A-dependent and independent effects of TPX2 overexpression on chromosome segregation and nuclear reconstitution at mitotic exit

    P.C84 • Francesca Orso • Turin
    miR-214 in tumor-stroma cell interactions

    P.C86 • Gianmarco Pallavicini • Orbassano (TO)
    Inactivation of microcephaly gene induces DNA damage and radiosensitization in medulloblastoma

    P.C88 • Eduardo Patriarca • Naples
    Self-organising gastruloids discriminate different states of pluripotency

    P.C90 • Simon Pellecchia • Naples
    The long non-coding RNA MPPED2-AS1 reduces the MPPED2 promoter methylation in breast cancer by binding DNMT1

    P.C92 • Sabrina Petralla • Bologna
    Proliferation/differentiation dysregulation in AGC1 deficiency brain precursor cells

    P.C94 • Manuela Piazzi • Bologna
    Expression of the double-stranded RNA-dependent kinase PKR influences osteosarcoma attachment independent growth, migration and invasion

    P.C96 • Giulia Pinton • Novara
    CDKN2A tips the balance of malignant pleural mesothelioma cell response to EZH2 inhibition

    P.C98 • Valeria Poli • Turin
    STAT3 transcriptional targets mediate the cross-talk between cancer associated fibroblasts and tumor cells conferring aggressiveness to mammary tumors

    P.C100 • Michela Pucci • Bologna
    Unveiling the role of the glycosyltransferase b4galnt2 and its cognate sda antigen in colorectal cancer

    P.C102 • Alessandro Rimessi • Ferrara
    Mitochondrial Calcium Uniporter controls lung inflammation in cystic fibrosis

    P.C104 • Francesca Russo • Aviano (PN)
    Large-scale evaluation of CDKN1B alteration in breast cancer reveals rare mutation incidence with frequent protein C-terminal truncation

    P.C106 • Aurora Savino • Turin
    Network analysis allows to unravel breast cancer molecular features and to identify novel targets

    P.C108 • Arianna Scalco • Padua
    Sympathetic neurotransmitters promote adipogenic differentiation of cardiac Mesenchymal Stromal Cell (c-MSCs) in Arrhythmogenic Cardiomyopathy (AC)

    P.C110 • Nouha Setti Boubaker • Tunis, Tunisia
    Clinical value of miR-205-5p, miR-27a-5p and miR-369-5p in tunisian patients with urinary bladder cancer

    P.C112 • Elisa Maria Turco • Rome
    Smith-Magenis syndrome patient derived cell line: molecular analysis of a newly described deletion in RAI1 gene

    P.C114 • Manuela Sollazzo • Bologna
    Cancer cells contribute to distinct malignant traits depending on their MYC and pJNK relative levels

    P.C116 • Tiziana Tempio • Milan
    Synergic regulation of post-endoplasmic reticulum quality control by ERp44, ERGIC-53 and KDELR

    P.C118 • Federico Torelli • Turin
    Characterization of SKT in the dendritic spines: a novel scaffold protein interacting with PSD-95 and Shank3

    P.C120 • Giulia Federici • Rome
    Can the mitotic centrosomal localization of p53 define ATM variants of uncertain significance (VUS)?

    P.C122 • Silvia Soddu • Rome
    Centrosomal p53 preserves spindle pole integrity and works as sensor for the mitotic surveillance pathway

    P.C124 • Ilaria Virdia • Rome
    Rapid, inducible, and reversible p53 degradation in nontransformed human cells by knock-in of auxin-inducible degron tag

    P.C126 • Sabrina Zema • Rome
    Maml1, not only a transcriptional co-activator of Gli1