Thursday, 19 September


Registration and posters set-up


Welcome and Opening of the Congress

Awarding of the "Luca Daveggio" prize


SIBBM Keynote Lecture

Chair: Pier Paolo Di Fiore (Milan)

Christer Betsholtz (Uppsala, Sweden)
A single-cell perspective on vascular biology


Session 1: Protein synthesis and degradation in cancer

Chair: Lucia Di Marcotullio (Rome)

Simona Polo (Milan, Italy)
Insights into HECT UB ligases: catalysis, regulation and inhibitors

Michele Carbone (Honolulu, HI, USA)
BAP1 cancer syndrome: how this gene regulate gene x environment interactions


Coffee break


Flash poster presentations

Chairs: Carlo Gaetano (Pavia), Giulia Piaggio (Rome)


Poster session 1


Buffet dinner

Friday, 20 September


Fondazione Umberto Veronesi Keynote Lecture

Chair: Paola Defilippi (Turin)

Sandra Schmid (Dallas, TX, USA)
Crosstalk between signaling and endocytosis in cancer cells


Session 2: Membrane contacts

Chair: Roberto Sitia (Milan)

Marco Sandri (Padua, Italy)
Mitochondrial dynamics in cellular homeostasis

Antonella De Matteis (Pozzuoli, NA, Italy)
ER-Golgi contact sites


Coffee break


Gennaro Ciliberto (FISV President)
FISV: mission and activities


Session 3: Cancer microenvironment

Chair: Gennaro Ciliberto (Rome)

Alberto Mantovani (Milan, Italy)
Innate immunity, inflammation and cancer: double edged swords

Adriana Albini (Milan, Italy)
Inflammation, angiogenesis and the tumor microenvironment as targets for cancer prevention


AIRC Keynote Lecture AIRC

Chair: Rudi Costa (Padua)

Michael W. Young (New York, NY, USA) • 2017 Nobel Laureate in Physiology or Medicine
Role of Drosophila’s blood brain barrier in sleep homeostasis


Lunch break


Session 4: Circadian clock

Chair: Massimo Santoro (Padua)

Michael Hastings (Cambridge, UK)
Cellular and molecular basis to circadian rhythms in mammals

Paolo Sassone-Corsi (Irvine, CA, USA)
Common threads: metabolism, epigenetics and the circadian clock


Keynote Lecture

Chair: Tom Kirchhausen (Boston, MA, USA)

Pier Paolo Di Fiore (Milan, Italy)
Subverted endocytosis and cancer: much more than meets the eyes


Coffee break


Session 5: Cancer cellular evolution

Chairs: Giuseppe Biamonti (Pavia), Gabriella Minchiotti (Naples)

Alberto Bardelli (Turin, Italy)
Adaptive mutability of cancers in response to targeted therapies

Giovanni Ciriello (Lausanne, Switzerland)
Cancer evolutionary templates: from statistical to functional relevance

Francesca Demichelis (Trento, Italy)
Cancer evolution studies, one allele at the time


Poster session 2


Buffet dinner

Saturday, 21 September


Keynote Lecture

Chair: Carmine Settembre (Pozzuoli, NA)

Maria Rescigno (Milan, Italy)
Microbiota and cancer progression


Session 6: Inflammation and immune response

Chairs: Matteo Iannacone (Milan), Antonio Musarò (Rome)

Alessandro Sette (La Jolla, CA, USA)
α-Synuclein-specific T cell reactivity is associated with preclinical and early stages of Parkinson’s disease

Antonella Viola (Padua, Italy)
The role of mitochondria in macrophage activation and functions

Haining Yang (Honolulu, HI, USA)
Mechanisms of asbestos carcinogenesis and cancer susceptibility


Coffee break


The EMBO Keynote Lecture EMBO

Chair: Carlotta Giorgi (Ferrara)

Bruce Beutler (Dallas, TX, USA) • 2011 Nobel Laureate in Physiology or Medicine
Using forward genetics to explore immunity in mice


Lunch break


Parallel Sessions (selected contributions from submitted abstracts)

A. From stress response to tissue development and regeneration

B. Signalling, membrane trafficking and organelle biogenesis

  • From stress response to tissue development and regeneration

    Chairs: Massimo Gulisano (Catania), Cristina Mazzoni (Rome)


    Stefania Farina (Pavia, Italy)
    ALS-linked mutation in FUS protein negatively impact on proper DNA damage response activation leading to damage accumulation


    Nunzio Vicario (Catania, Italy)
    Neuroglial axis and immune cells role in a mouse model of motoneuronal ablation


    Caterina Gasperini (Genoa, Italy)
    Identification of piRNAs and functional investigation of piRNA-pathway in adult mammalian Neural Progenitor Cells


    Francescopaolo Iavarone (Naples, Italy)
    Cripto modulates macrophage phenotypes and controls endothelial plasticity by restricting EndMT in skeletal muscle injury and Duchene muscular dystrophy


    Alessandra Barbiera (Rome, Italy)
    Role of taurine to counteract the loss of muscle mass and function characteristic of senescent muscle


    Teresa Rinaldi (Rome, Italy)
    Mitochondrial oxidative stress modulates the NEDD8/Rub1 conjugation pathway in S. cerevisiae


    Giuseppe Caruso (Troina, EN, Italy)
    Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism and mitochondrial dysfunction in microglial and alveolar basal epithelial cells


    Luisa de Latouliere (Rome, Italy)
    Mice and fishes illuminate diseases: a new era of preclinical oncology models


    Lina Ghibelli (Rome, Italy)
    Anakoinosis: an innovative anticancer therapy targeting the aberrant cancer tissue homeostasis


    Raffaele Strippoli (Rome, Italy)
    Mechanical stretch triggers TGF-β1 autocrine production causal to YAP/Caveolin1 activities: implications in peritoneal fibrotic pathologies

  • Signalling, membrane trafficking and organelle biogenesis

    Chairs: Barbara Belletti (Aviano, PN), Carmen Valente (Naples)


    Sirio Dupont (Padua, Italy)
    Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP


    Maurizio Renna (Naples, Italy)
    Unconventional secretion of the small heat-shock protein α-Crystallin B requires the autophagic pathway and is controlled by phosphorylation of its serine 59 residue


    Laura Cinque (Pozzuoli, NA, Italy)
    Transcriptional regulation of ER-phagy by MiT/TFE factors controls chondrocyte differentiation and bone formation


    Rosaria Di Martino (Naples, Italy)
    Control systems regulating export from the TGN: a role of an orphan GPCR in basolateral cargo delivery and cell polarity


    Thomas Vaccari (Milan, Italy)
    The SNARE protein SNAP29 at the endoplasmic reticulum arrival sites: unconventional action and a blueprint for kinetochore formation


    Elisa Barbieri (Milan, Italy)
    Connecting the EGFR to the ER: the role of PLCG2 in non-clathrin endocytosis


    Chiara Di Malta (Pozzuoli, NA, Italy)
    Deregulation of MiT/TFE-mTORC1 crosstalk promotes cancer growth


    Simone Patergnani (Ferrara, Italy)
    Antidepressants targeting the ubiquitin-proteasome-autophagy pathway increase mesothelioma response to chemotherapy


    Maria Chiara De Santis (Turin, Italy)
    PI3K-C2γ loss promotes pancreatic cancer through mTOR regulation and metabolic rewiring


    Rossella Venditti (Pozzuoli, NA, Italy)
    The PI4P sensor FAPP1 regulates cell invasion by controlling secretion of pro-metastatic factors


Coffee break


Session 7: Stem cells in development and cancer: from single cell to organoids

Chair: Cecilia Bucci (Lecce)

Giulio Cossu (Manchester, UK)
Cell mediated exon skipping for the therapy of Duchenne Muscular Dystrophy

Nicola Valeri (London, UK)
Patient-derived organoids for personalized cancer treatment


Awarding of the "Guido Berlucchi Foundation" prizes


ABCD Assembly


Social dinner (Salotto Boschi, Bologna)


The poster's maximum size is A0 (841 x 1189 mm; width x height).

Correct format... poster should be PORTRAIT    poster should NOT be LANDSCAPE Wrong format...

All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned. You are kindly invited to put up your poster upon arrival, from Thursday at 14:00 onwards, and in time for the first poster session. Posters should be taken down before 18:00 on Saturday, 21 September.


  • Thursday, 19 September • 19:00-22:30

    P.A1 • Tiziana AnelliMilan
    Decidualization entails profound architectural and functional readjustments of the secretory pathway in endometrial stromal cells

    P.A3 • Eustachio AtticoModena
    Identification of markers to univocally distinguish human oral mucosa epithelium from cornea and conjunctival tiussues

    P.A5 • Francesco CapradossiRome
    Post therapy cancer repopulation: from DNA damage to tissue regeneration

    P.A7 • Gabriele D'UvaMilan
    Direct stimulation of cardiomyocyte regenerative plasticity by steroid hormone modulation

    P.A9 • Chiara De LeonibusNaples
    Study of the function and physiological roles of the ER-phagy receptor FAM134B during skeletal development in Medaka model

    P.A11 • Giovanni DothelBologna
    Secondary bile acid effect on neuronal sprouting evoked by mast cells – an in vitro model of neuro-immune interaction

    P.A13 • Marialucia GalloriniChieti
    Hyaluronic acid enhances recovery from inflammation through the activation of Nrf2-related pathways in human tenocytes

    P.A15 • Nicoletta GuaragnellaBari
    Exploring the therapeutic potential of 6-Thioguanine and its Analogs in the treatment of BRCA2-deficient castration-resistant prostate cancers

    P.A17 • Giovanna LattanziBologna
    Inhibition of inflammatory cytokines improves the disease phenotype in laminopathic cells

    P.A19 • Marina MapelliMilan
    Molecular crosstalk between fate determination and orientation in epithelial cell divisions

    P.A21 • Simona MartinottiAlessandria
    Honey-Mediated Wound Healing: H2O2 Entry through AQP3

    P.A23 • Elisa MentegariPavia
    Characterisation of a novel alternative end-joining pathway independent from DNA-PKcs

    P.A25 • Tatiana Pinheiro TiagoModena
    HSPB3 and HSPB2: unexpected functions in the regulation of nuclear homeostasis

    P.A27 • Elia RanzatoAlessandria
    Elevated GRP78 expression in malignant mesothelioma

    P.A29 • Simone SabbioniMilan
    A RBX1/FBXW8-based SCF-type E3 ligase complex mediates Numb degradation in breast cancer

    P.A31 • Valeria ValenteNaples
    Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice

    P.B1 • Filippo AcconciaRome
    The natural ERα L370F and E471D mutations found in metastatic breast cancers are resistant to classic and novel anti-estrogens

    P.B3 • Mattia ApollonioTrieste
    Regulation of tumor suppressor DAB2IP by mechanical cues

    P.B5 • Elisa BarbieriMilan
    Role of ER contact sites, calcium and mitochondria in EGFR endocytosis

    P.B7 • Leonardo BarzaghiMilan
    RAB5 family members in the control of phase transition during collective motion and cancer progression

    P.B9 • William BlalockBologna
    AKT-depedent phosphorylation of the adenosine deaminases, ADAR1 and ADAR2, on a conserved threonine residue in the catalytic domain differentially inhibits deaminase activity

    P.B11 • Claudia BusoneroRome
    Ouabain induces ERα degradation and prevent 17β-estradiol (E2)-induced breast cancer cell proliferation

    P.B13 • Concettina CappadoneBologna
    Magnesium deficiency regulates proliferation of human osteosarcoma cells: single cell magnesium distribution by XRFM and STXM techniques

    P.B15 • Barbara ColellaPesche (IS)
    Glioblastoma-Initiating Cells: a tool to study autophagy role in GBM pathogenesis

    P.B19 • Alberto DaneseFerrara
    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy (LHON)

    P.B21 • Abhishek DerleTurin
    Role of PI3KC2A in Modulating the Glucose Homeostasis

    P.B23 • Giorgia Di LorenzoPozzuoli (NA)
    Regulation of cellular metabolism by ER-phagy

    P.B25 • Maristella LaggettaAncona
    In vitro pro-inflammatory effects of nongluten ATIs obtained from different wheat species

    P.B27 • Miriam GaggianesiPalermo
    A synthetic lethal approach: Sam68 and Rad51 inhibition for the eradication of breast cancer stem cells

    P.B29 • China GenchiMilan
    A comprehensive strategy to characterize new Notch regulators

    P.B31 • Federico GiulittiRome
    Different response to oleic acid administration in hepatocellular carcinoma vs non tumorigenic hepatocyte cell lines

    P.B33 • Daniela GuarnieriFisciano (SA)
    The study of the intracellular fate of nanomaterials: how to design safe and effective drug delivery systems

    P.B35 • Andrea LamarcaMilan
    Mechanisms of assembly and function of plasma membrane–associated platforms at the front of migrating cells

    P.B37 • Ludovica Lospinoso SeveriniRome
    SALL4A is a new positive regulator of Hedgehog signalling involved in medulloblastoma tumorigenesis

    P.B39 • Stefano MarchesiMilan
    IRSp53 controls kidney morphogenesis through regulation of epithelial polarity and lumenogenesis

    P.B41 • Fabiola MascanzoniNaples
    Golgi unlinking is essential for correct spindle formation and cytokinesis

    P.B43 • Valentina MorraPozzuoli (NA)
    Role of the PI(4,5)P2 5-phosphatase OCRL at the synapse

    P.B45 • Dora NataliniTurin
    Regulation of mevalonate pathway by p140Cap in breast cancer cells

    P.B47 • Antonio PezoneNaples
    Targeted G and C DNA oxidation couples histone and DNA methylation cycles to drive transcription induced by nuclear hormones

    P.B49 • Prathyush PothukuchiNaples
    Grasp55 regulates glycosphingolipid biosynthesis by controlling the localization of glycosylation enzymes

    P.B51 • Danilo RanieriRome
    Role of PKCε and PKCα in the control of the epithelial-mesenchymal transition induced by the FGFR2 altered splicing

    P.B53 • Simona RicciardiPozzuoli (NA)
    Role of phosphatidylserine (PS) and PS binding proteins in ER-Golgi contact sites

    P.B55 • Riccardo RizzoNaples
    From Golgi dynamics to glycan processing to function: GOLPH3 retrotransports selected glycoenzymes across maturing cisternae to generate growth-promoting glycosphingolipid patterns

    P.B57 • Emanuela SenatoreNaples
    Coupling cAMP signalling to primary ciliogenesis by a TBC1D31-centered centrosomal complex

    P.B59 • Michela SgubinTrieste
    HMGA1/p27/stathmin axis promotes migration in triple negative breast cancer (TNBC) cells

    P.B61 • Leopoldo StaianoPozzuoli (NA)
    A combined in vitro and in vivo approach for the identification of correctors of Lowe Syndrome

    P.B63 • Luana TomaipitincaRome
    c-FLIP protein regulates autophagic flux by interacting with Beclin-1 and influencing its stability

    P.B65 • Rossella VendittiPozzuoli (NA)
    Regulation and function of endoplasmic reticulum-Golgi contact sites

    P.B67 • Narender KumarNaples
    A cell-autonomous PD-1/PD-L1/2 circuit promotes proliferation and motility of thyroid cancer cells by potentiating the Ras/Erk signalling cascade

    P.C1 • Davide AdamoModena
    Human airway epithelial cell expansion: fittest culture conditions for tissue engineering applications

    P.C3 • Adriana AmaroGenoa
    Secondary somatic driver mutations in G-protein related pathways and mutation signatures in uveal melanoma

    P.C5 • Matteo AstonePadua
    Clock ticks during angiogenesis: dissecting the endothelial role of circadian clock gene Bmal1

    P.C9 • Chiara BernardiniOzzano Emilia (BO)
    Effect of H2S on porcine Vascular Wall-Mesenchymal Stem Cell physiology

    P.C11 • Amani BouzidiRome
    Serine and glycine rewire lung  adenocarcinoma metastases metabolism

    P.C13 • Licia BressiBologna
    P53 sustains oxidative metabolism and delays the energetic collapse caused by targeting respiratory complex I in combination with low glucose

    P.C15 • Electra BrunialtiMilan
    Morpho-functional analysis of microglia in a cell culture model of Gaucher disease

    P.C17 • Gaia ButeraPadua
    Mitochondrial adaptation in parvalbumin knockout muscle fibers

    P.C19 • Andrea CastiglioniMilan
    NCAM1/CD56 is a determinant of self-renewal and tumorigenic ability in prostate cancer stem cells

    P.C21 • Francesca ChiariniBologna
    Lamin A behaves as a tumor suppressor in Ewing Sarcoma triggering neural differentiation and reducing cell migration and invasion

    P.C23 • Claudia ContadiniRome
    SRC-dependent phosphorylation of Caspase-8 on Tyr380 contributes to NFkB activation and inflammatory tumor microenvironment in Glioblastoma

    P.C25 • Valeria CutilloMilan
    Spatiotemporal regulation of type I interferon expression determines antiviral CD4T cell polarization

    P.C27 • Michela DamiziaRome
    RANBP2: a nucleoporin with key roles in SUMOylation of mitotic proteins

    P.C29 • Maria Giovanna de MarinoBusto Arsizio
    ERG promotes the methylation reprogramming in prostate cancer onset

    P.C31 • Donatella Delle CaveNaples
    TGF-β promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the L1CAM

    P.C33 • Anna Di BonaPadua
    Generation and phenotyping of novel knock-in (KI) mouse models of Arrhythmogenic Cardiomyopathy (AC)

    P.C35 • Francesco Di MeoNaples
    In vitro and in vivo anticancer activity of curcumin standardized extract on mesothelioma

    P.C37 • Riccardo TurchiRome
    Frataxin deficiency causes brown adipose tissue dysfunctions: possible implication in diabetes development in Friedreich’s ataxia

    P.C39 • Federica FeoNaples
    Functional characterization of the transcription factor FOXE1 in the Non-Melanoma Skin Cancers tumorigenesis

    P.C41 • Manuela FerraraRome
    HIPK2/spastin axis: cytokinesis failure and tumorigenesis in pancreatic cancer

    P.C43 • Diego FerreriRome
    Unmasking the role of Drosophila Tip60 chromatin remodelling complex in male meiosis and spermatogenesis

    P.C47 • Rosaria Anna FontanellaRome
    Functional and molecular characterization of a metastatic prostate cancer PC3 subpopulation expressing CD44v8-10

    P.C49 • Antonio GaleoneMilan
    Regulation of BMP signaling by N-glycanase 1 (NGLY1)

    P.C51 • Ramesh GandusekarBusto Arsizio
    Regulation of H2B monoubiquitination (H2BK120) by UHRF1 in Colorectal Cancer

    P.C53 • Eugenia GiulianiRome
    Notch3 contributes to T-cell leukemia growth via regulation of the unfolding protein response

    P.C55 • Marika GuerraRome
    Splicing dysregulation of genes encoding for synaptic proteins as risk factor in autism spectrum disorder

    P.C57 • Aymone GurtnerRome
    Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

    P.C59 • Myriam HsuTurin
    Several models of skeletal muscle wasting display altered iron metabolism

    P.C61 • Francesco LasorsaBari
    Investigation of pathogenetic mechanisms of AGC1 deficiency in iPS cells-derived neuron progenitor cells of patient

    P.C63 • Mattia LauriolaBologna
    Glucocorticoid receptor modulates EGFR feedback in the acquisition of resistance to monoclonal antibodies

    P.C65 • Debora LibettiMilan
    Role of NF-YA isoforms in mouse Embryonic Stem Cells

    P.C67 • Rossella LucàMonterotondo (RM)
    MDM4 function and its prognostic potential in ovarian cancer progression

    P.C69 • Jessica MarinelloBologna
    Development of new G4 binders in cancer therapy: synthesis, biophysical and biological studies of hydrazones derivatives

    P.C71 • Martina MazzeschiBologna
    Pharmacological inhibition of the ALK/MET axis elicits therapeutic potential in consensus molecular subtype 1 colon cancer patients

    P.C73 • Giovanni MessinaRome
    Evolutionary conserved recruitment of ATP-dependent chromatin remodelling complexes to mitotic apparatus prevent failure of mitosis and genome instability

    P.C75 • Sonia MissiroliFerrara
    Loss of PML promotes NLRP3 inflammation-associated cancer in a P2X7 dependent manner

    P.C77 • Halenya MonticelliPadua
    Role of mitochondrial Ca2+ uniporter in breast cancer

    P.C79 • Giampaolo MorcianoFerrara
    Novel polymorphisms in ATP5G1-3 genes are associated to poor clinical outcomes in patients affected by Myocardial Infarction

    P.C81 • Francesca NardozzaRome
    Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance

    P.C83 • Francesco NicassioMilan
    MicroRNA degradation in human physiology and pathology

    P.C85 • Simona PagliaBologna
    A neurogenic model of adult brain cancer in Drosophila

    P.C87 • Harikrishnareddy PaluvaiUdine
    Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favours cell transformation

    P.C89 • Annalisa PecoraroNaples
    Cyclin D1 and E2F1: novel targets of uL3 in cancer cell response to ribosomal stress

    P.C91 • Mariasole PerroneFerrara
    Loss of PML reduces radiotherapy efficacy through NLRP3 inflammasome activation

    P.C93 • Alex PezzottaSegrate (MI)
    A new candidate gene involved in nervous system myelination: functional in-vivo validation using a zebrafish model system

    P.C95 • Giovanna PiconeBologna
    Osteogenic differentiation of osteosarcoma cells: role of Mg in the early stages of mineral formation of hydroxyapatite

    P.C97 • Fabrizio PizzettiBologna
    Interplay between CYYR1 gene and Sonic hedgehog pathway: from zebrafish myogenesis to a potential role in rhabdomyosarcoma disease

    P.C99 • Federica PolverinoRome
    Spindle orientation is regulated by the Aurora-A/TPX2 axis and contributes to faithful chromosome segregation

    P.C101 • Gian Luca Rampioni VinciguerraAviano (PN)
    p27kip1 regulates haematopoiesis by inducing Notch signalling pathway

    P.C103 • Paola RovellaRome
    Importin beta-1 regulates the centromeric protein CENP-F during mitosis

    P.C105 • Chiara SalisRome
    Long non-coding RNA MALAT-1 acts as a master controller of cellular metabolism in prostate cancer

    P.C107 • Silvia SbernaMilan
    Characterization of novel YAP/TAZ regulators

    P.C109 • Emanuela ScavoPalermo
    Cancer stem cells define thyroid cancer heterogeneity

    P.C111 • Silvia SideriRome
    Role of toll like receptors stimulation in the mechanism involved in radioresistance of prostate cancer

    P.C113 • Stefano SolNaples
    Epidermal p63 is essential to control systemic levels of TSLP through repression of KLK6

    P.C115 • Silvia SorrentinoRome
    Temozolomide effect on glioblastoma stem cell proliferation and apoptosis is enhanced by Levetiracetam treatment

    P.C117 • Camilla TombariTrieste
    Dissecting the oncogenic functions of mutant P53 R249S in hepatocellular carcinoma

    P.C119 • Nesrine TrabelsiTunis, Tunisia
    Notch pathway: bioinformatic analysis of related transcription factors within bladder cancer types and subtypes

    P.C121 • Chiara TurcoRome
    Induction of ID4 protein contributes to tumor-associated macrophages reprogramming in breast cancer

    P.C123 • Roberta VazzanaMilan
    The role of fatty acids on the metabolic reprogramming of breast cancer cells

    P.C125 • Elisabeth WyartTurin
    Altered iron metabolism promotes cancer cachexia

    P.C127 • Michele ZocchiBusto Arsizio
    Identifying cancer driver transcripts in ERG+/PTEN- RWPE-1 PCa onset in vitro model

  • Friday, 20 September • 19:00-22:30

    P.A2 • Andrea GrazianiTurin
    Colon carcinoma (C26) conditioned medium attenuates the adrenergic signaling in C2C12 muscle cell line

    P.A4 • Ilaria CamponeschiRome
    Lipid metabolism connects the response to oxidative stress and longevity in yeast

    P.A6 • Vittoria CenniBologna
    Emerin post-translational modifications are affected during early phase of oxidative stress response

    P.A8 • Luisa de LatouliereRome
    Mice and fishes illuminate diseases: a new era of preclinical oncology models

    P.A10 • Isabella ManniRome
    Imaging of proliferation during mammary tumorigenesis reveals a crosstalk between cancer and host macroenviroment

    P.A12 • Simone FonteRome
    Loss of the Hedgehog pathway suppressor KCASH2 in mouse leads to mild cerebellar phenotype and altered behaviour

    P.A14 • Elena GenoveseModena
    Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

    P.A16 • Lucia InfantinoPavia
    Cell metabolism influences the splicing program of SRSF1 transcripts

    P.A18 • Giacomo DonatiTurin
    Integrating genetics screening approaches to identify chromatin key factors of epidermal cell plasticity

    P.A20 • Serena MarcozziRome
    Protection from cisplatin-induced ovarian damage by human mesenchymal stromal cells in vitro

    P.A22 • Silvia MasciarelliRome
    Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce AML cell death

    P.A24 • Giorgia PallafacchinaPadua
    MCU-mediated mitochondrial Ca2+ uptake is required for zebrafish motor neuron network and skeletal muscle development and adult tissue physiology

    P.A26 • Erica PrioriPavia
    Oxidative stress and inflammatory pathways evaluation in prolidase deficient mice: a cerebellar study during postnatal development

    P.A28 • Giovanna RigilloModena
    The transcription factor NF-Y is required for satellite stem cell proliferation and skeletal muscle tissue repair

    P.A30 • Simona SalaMilan
    Characterization of HECW1 role in neuronal homeostasis

    P.A32 • Valentina VaporeRome
    Yeast response to the expression of human proteins involved in serpinopathies

    P.B2 • Ilenia AgliaruloNaples
    Identification of new glycosylation-related oncogenes in non-small cell lung cancer

    P.B4 • Lucia BarazzuolPadua
    In vitro and in vivo investigation of intracellular organelle contacts with novel modular genetically encoded sensors

    P.B6 • Stefania BartoloniRome
    An unexpected role for 17β-estradiol-induced replication stress in breast cancer cell proliferation

    P.B8 • Arianna BellazzoTrieste
    Cell-autonomous and cell non-autonomous downregulation of the tumor suppressor DAB2IP by microRNA-149-3p promotes cancer progression by microenvironment remodeling

    P.B10 • Mara BrancaccioTurin
    Morgana intracellular and extracellular functions in breast cancer progression

    P.B12 • Miriam CaimanoRome
    Self-assembling polymers for glabrescione b delivery for hedgehog-dependent tumor treatment

    P.B14 • Natascia CarocciaFerrara
    Investigation on the molecular mechanisms involved in melatonin action as neuroprotective agent

    P.B16 • Sara ColomboMilan
    Role of rare missense variants of the human β4 subunit in the expression and surface exposure of α3β4 nicotinic receptors

    P.B18 • Giulia CricrìMonza
    Effect of activinA on b-cell precursor acute lymphoblastic leukemia (BCP-ALL) cell vesiculation

    P.B20 • Angela Della SalaTurin
    cAMP regulation by a PI3Kg mimetic peptide as a therapeutic strategy to restore CFTR function

    P.B22 • Simone Di FrancoPalermo
    Visceral adiposity drives colon cancer progression

    P.B24 • Alessandra EspositoPozzuoli (NA)
    A non-canonical mTOR signaling mediated by Rag GTPases modulates TFEB activity

    P.B26 • Francesca FinettiSiena
    The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases

    P.B28 • Camilla GalliMilan
    Dynamic hand-in-hand cooperation between spectrin and actin during mammalian cell mechanoresponses

    P.B30 • Luisa GesualdiRome
    ERK role in the c-MET-mediated proliferating behaviour of NT2D1 non-seminoma cells

    P.B32 • Paolo GrumatiPozzuoli (NA)
    ER-phagy receptors and co-receptors for specific ER turnover

    P.B34 • Flora GuerraLecce
    Extracellular vesicle secretion is mediated by RAB7: implications of late endocytic impairment in cisplatin chemoresistance

    P.B36 • Erica LeonettiRome
    c-Met-mediated pathway in malignant behaviour acquisition of NT2D1 non-seminoma cells: role of PI3K/AKT and c-Src adaptors

    P.B38 • Valeria MalacarneTurin
    DGKα controls glioblastoma tumorigenesis by regulating β1 integrin endocytosis and focal adhesion turnover

    P.B40 • Maria Vittoria MarviBologna
    Inositide-dependent signalling in low- and high-grade gliomas

    P.B42 • Maria Caterina MioneTrento
    Role of Bap1 in the biogenesis and function of extracellular vesicles in  zebrafish melanoma

    P.B44 • Michela NapolitanoNaples
    Mechanisms of CtBP1-S/BARS-mediated mitotic Golgi fragmentation

    P.B46 • Gaia PedrialiFerrara
    New permeability transition pore inhibitors for the treatment of reperfusion damage

    P.B48 • Elena PirettoMilan
    EGFR trafficking and signalling: insights from mathematical modelling

    P.B50 • Emanuela PupoCandiolo
    TBC1D7, a subunit of the TSC1/TSC2 complex, elevates glycolysis in breast cancer by promoting mTORC2 signaling

    P.B52 • Paolo RemondelliBaronissi (SA)
    PERK-mediated Unfolded Protein Response activation and oxidative stress in PARK20 fibroblasts

    P.B54 • Veronica RiccioniRome
    Identification of RNA Binding Proteins (RBPs) regulating sequence-specific miRNA sorting in exosomes

    P.B56 • Anna Scotto RosatoNaples
    TRPML1 links lysosomal calcium to autophagosome biogenesis

    P.B58 • Maria Concetta SergioPozzuoli (NA)
    Vesicular trafficking is required for the arrival and retrieval of Syntaxin 17 from autophagosomes

    P.B60 • Diletta SicilianoPozzuoli (NA)
    Analysis of the physiological relevance of TFEB phosphorylation in vivo

    P.B62 • Claudia TitoRome
    Long non-coding RNAs contribution to cell migration and lipid metabolism in thymic epithelial tumor cells

    P.B66 • Lucrezia ZerilloNaples
    Dysregulation of autophagy has a potential role in Synj1-associated early-onset parkinsonism

    P.C2 • Serena AleoBologna
    Mitochondrial alterations in lysosomal storage disorders: is this the case of fabry disease?

    P.C4 • Mohammad Salik Zeya AnsariRome
    Identification of novel p300/CBP selective HAT inhibitor in lung cancer as a future therapeutic strategy by epigenetic therapy

    P.C6 • Denisa BaciVarese
    Acetyl-L-carnitine (ALCAR), novel anti-inflammatory and anti-angiogenic agent in prostate cancer

    P.C7 • Marina BelletPerugia
    The circadian clock controls the outcome of fungal infections

    P.C8 • Silvia BellutiModena
    Switch of NF-YA splice variants in prostate cancer development and progression

    P.C10 • Bartolo BonoPavia
    Kinetic characterization of CK1ε and DDX3X interplay

    P.C12 • Enrico BraccoOrbassano (TO)
    Finding novel roles for large HERC E3-ubiquitin ligases in Dictyostelium and leukemic cells

    P.C14 • Elisabetta BroseghiniBologna
    Understanding the biology of multiple primary melanoma

    P.C16 • Samantha BrunoBologna
    Deep hypoxia and the genomic background cooperate to shape the metabolic profile of acute myeloid leukemia cells

    P.C18 • Serena CarraModena
    Defective ribosomal products (DRiPs) challenge nuclear function by impairing nuclear condensate dynamics

    P.C20 • Mariano CatanesiL'Aquila
    YAP/TAZ mechano-transduction as the underlying mechanism of neuronal differentiation induced by reduced graphene oxide

    P.C22 • Barbara CianiSheffield, United Kingdom
    ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

    P.C24 • Salvatrice CiccareseBari
    Evolution of the T cell receptor (TR) loci in mammalian adaptive immune response

    P.C26 • Michele d'AngeloL'Aquila
    The PPARα selective antagonist, GW6471 inhibits cell growth in breast cancer stem cells inducing energy imbalance and metabolic stress

    P.C28 • Luca De FeoMilan
    Molecular characterisation of transplanted neural progenitor cells in a multiple sclerosis animal model

    P.C30 • Giorgia De SimoneMilan
    Spatiotemporal dynamics and genomic landscape of CD8+T cells undergoing intrahepatic priming unveil IL-2 as a key immunotherapy component against chronic HBV infection

    P.C32 • Francesca Delle MonacheRome
    Uncovering the role of the Tip60 chromatin remodelling complex in Drosophila cell division

    P.C34 • Lucia Di MarcotullioRome
    Oncogenic role of the aminopeptidase ERAP1 in Hedgehog-dependent cancer

    P.C36 • Francesca FabrettiRome
    Dual role of NBS1 in SHH-dependent medulloblastoma

    P.C38 • Albina FejzaAviano (PN)
    Emilin 2 as a regulator of vascular efficiency

    P.C40 • Manuela FerracinBologna
    Evaluation of cGAS/STING expression as a marker of tumor immunogenicity

    P.C42 • Beatrice FerrariPavia
    A new platinum-based prodrug candidate: its anticancer effects and in vitro approaches to understand novel target to treat Glioblastoma multiforme

    P.C44 • Nicoletta FilighedduNovara
    The role of vitamin D binding protein in the onset of cancer cachexia - beyond vitamin D transport 

    P.C46 • Fabrizio FontanaMilan
    δ-Tocotrienol induces mitochondrial dysfunction and inhibits glycolysis in prostate cancer cells

    P.C48 • Valeria FumagalliMilan
    The role of group 1 innate lymphoid cells (ILCs) in liver immunopathology

    P.C50 • Gloria GanduscioPalermo
    Preliminary evaluation of CD44v6/PD-L1 expression as new therapeutic target in CR-CSCs

    P.C52 • Sabrina GarboRome
    A lncRNA HOTAIR mutant form counteracts the Epithelial-to-Mesenchymal Transition (EMT) by interfering with Snail function

    P.C54 • Luca GozzelinoTurin
    Characterization of PI3KC2β in the pathogenesis of Focal Epilepsy

    P.C56 • Eugenia GuidaRome
    BRAFV600E mutation in combination with loss of tumor suppressor Pten in adult Neural Stem/Progenitor Cells induces glioma formation

    P.C58 • Benjamin HersheyMilan
    Tumor ecology, an investigation into the functional role of intra-tumoral metabolic heterogeneity

    P.C60 • Luisa IommariniBologna
    Induction of pseudo-normoxia to prevent hypoxic adaption in tumorigenesis

    P.C62 • Ivana KurelacBologna
    Targeting mitochondrial complex I in cancer triggers macrophage-mediated survival mechanisms

    P.C64 • Elisa LeporeRome
    Metabolic changes associated with muscle expression of SOD1G93A

    P.C66 • Ilaria LorenzonAviano (PN)
    Inhibition of SGK2, a novel autophagy modulator, sensitizes cancer cells to platinum drugs

    P.C68 • Natascia MalerbaSan Giovanni Rotondo(FG)
    Cell modelling and electrophysiological characterization to dissect the pathogenic consequences of G-protein beta 5 subunit mutations

    P.C70 • Luisa MarracinoFerrara
    17β-Estradiol-mediated modulation of  Notch1  in murine macrophage cell line Raw 264.7

    P.C72 • Diego MedinaNaples
    Repositioning of FDA-approved drugs for the treatment of Mucopolysaccharidoses (MPSs)

    P.C74 • Stefano MigliettaBologna
    Role of MCJ/DNAJC15 in mitochondrial metabolism rewiring of chemoresistant ovarian cancer cells

    P.C76 • Francesca MontaniMilan
    Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: a retrospective consecutive study

    P.C78 • Pascale MonzoMilan
    Implication of formins in the regulation of mechanoproperties of invasive gliomas

    P.C80 • Francesco MorraNaples
    Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma

    P.C82 • Francesco NasoRome
    Aurora-A-dependent and independent effects of TPX2 overexpression on chromosome segregation and nuclear reconstitution at mitotic exit

    P.C84 • Francesca OrsoTurin
    miR-214 in tumor-stroma cell interactions

    P.C86 • Gianmarco PallaviciniOrbassano (TO)
    Inactivation of microcephaly gene induces DNA damage and radiosensitization in medulloblastoma

    P.C88 • Eduardo PatriarcaNaples
    Self-organising gastruloids discriminate different states of pluripotency

    P.C90 • Simon PellecchiaNaples
    The long non-coding RNA MPPED2-AS1 reduces the MPPED2 promoter methylation in breast cancer by binding DNMT1

    P.C92 • Sabrina PetrallaBologna
    Proliferation/differentiation dysregulation in AGC1 deficiency brain precursor cells

    P.C94 • Manuela PiazziBologna
    Expression of the double-stranded RNA-dependent kinase PKR influences osteosarcoma attachment independent growth, migration and invasion

    P.C96 • Giulia PintonNovara
    CDKN2A tips the balance of malignant pleural mesothelioma cell response to EZH2 inhibition

    P.C98 • Valeria PoliTurin
    STAT3 transcriptional targets mediate the cross-talk between cancer associated fibroblasts and tumor cells conferring aggressiveness to mammary tumors

    P.C100 • Michela PucciBologna
    Unveiling the role of the glycosyltransferase b4galnt2 and its cognate sda antigen in colorectal cancer

    P.C102 • Alessandro RimessiFerrara
    Mitochondrial Calcium Uniporter controls lung inflammation in cystic fibrosis

    P.C104 • Francesca RussoAviano (PN)
    Large-scale evaluation of CDKN1B alteration in breast cancer reveals rare mutation incidence with frequent protein C-terminal truncation

    P.C106 • Aurora SavinoTurin
    Network analysis allows to unravel breast cancer molecular features and to identify novel targets

    P.C108 • Arianna ScalcoPadua
    Sympathetic neurotransmitters promote adipogenic differentiation of cardiac Mesenchymal Stromal Cell (c-MSCs) in Arrhythmogenic Cardiomyopathy (AC)

    P.C110 • Nouha Setti BoubakerTunis, Tunisia
    Clinical value of miR-205-5p, miR-27a-5p and miR-369-5p in tunisian patients with urinary bladder cancer

    P.C112 • Elisa Maria TurcoRome
    Smith-Magenis syndrome patient derived cell line: molecular analysis of a newly described deletion in RAI1 gene

    P.C114 • Manuela SollazzoBologna
    Cancer cells contribute to distinct malignant traits depending on their MYC and pJNK relative levels

    P.C116 • Tiziana TempioMilan
    Synergic regulation of post-endoplasmic reticulum quality control by ERp44, ERGIC-53 and KDELR

    P.C118 • Federico TorelliTurin
    Characterization of SKT in the dendritic spines: a novel scaffold protein interacting with PSD-95 and Shank3

    P.C120 • Giulia FedericiRome
    Can the mitotic centrosomal localization of p53 define ATM variants of uncertain significance (VUS)?

    P.C122 • Silvia SodduRome
    Centrosomal p53 preserves spindle pole integrity and works as sensor for the mitotic surveillance pathway

    P.C124 • Ilaria VirdiaRome
    Rapid, inducible, and reversible p53 degradation in nontransformed human cells by knock-in of auxin-inducible degron tag

    P.C126 • Sabrina ZemaRome
    Maml1, not only a transcriptional co-activator of Gli1